SEC EDGAR / S-1, S-1/A, 424B4

What life-sciences
IPO filers had to prove

A filing-by-filing record of the US biotech, medical device, diagnostics and healthcare services companies that priced IPOs since July 2025. Each entry links to the original SEC documents and shows which clinical, regulatory, quality, commercial and financial evidence the final prospectus discloses

See what each sector had to prove

Compiled from SEC EDGAR and first published on this site in September 2026. Event dates are the filing dates SEC records; they are not the dates this page was written

Priced IPOs38
SEC filing records403
Quarters4 complete + 1 partial
CollectedSeptember 2026

01 / sector evidence

Same SEC process, different things to prove

Biotech, device and services prospectuses go through the same registration review but make different kinds of case. The counts below come from the 38 final prospectuses on this page

Biotech and pharma · 25 prospectuses

Show the path from trial data to an approvable product

These prospectuses are built around the clinical programme. Every one discusses the investigational new drug (IND) stage and the marketing application ahead (NDA or BLA). 24 of 25 discuss topline data readouts and 18 of 25 discuss pivotal studies. Manufacturing is mostly outsourced: 25 of 25 describe reliance on contract manufacturers. The financial case is about runway: 21 of 25 say how long the cash will fund operations, and 9 of 25 include an auditor going-concern paragraph

What a reviewer asks: which data supports the next milestone, and does the cash reach it?
Medical device and diagnostics · 11 prospectuses

Show clearance, quality systems and a route to payment

These prospectuses name a specific FDA pathway: 10 of 11 discuss 510(k) clearance and 11 of 11 discuss PMA or De Novo. Quality-system regulation or ISO 13485 appears in 11 of 11, and 9 of 11 address CE marking or EU device regulation. Reimbursement is part of the case: 7 of 11 discuss CPT or HCPCS billing codes. Material weaknesses in internal control were disclosed by 3 of 11

What a reviewer asks: is the product cleared, can it be made consistently, and who pays for it?
Healthcare services · 2 prospectuses

Show a lawful operating model and payer economics

Only two services companies priced in this window, so they are two case records rather than a pattern. Both address HIPAA, the Anti-Kickback Statute and the Stark Law. One discusses the corporate practice of medicine and one discusses certificate-of-need rules. Here the evidence is about the operating structure and who pays, not about clinical trials

What a reviewer asks: is the operating structure compliant, and is the payer mix durable?
Across all 38

The same review process, very different evidence

37 of 38 issuers started with a confidential draft registration statement. The median time from that first submission to pricing was 163 days across the four complete quarters, and the median issuer filed 2 public S-1 amendments. The SEC process is shared. What differs by sector is what goes into it

These counts describe 38 filings. They do not describe the whole market

02 / signal matrix

Where each evidence theme shows up

Each signal is a fixed phrase searched in the final prospectus text. Risk factors often mention a topic as a possibility, so a hit shows the topic is disclosed, not that it happened. The dictionary is on the methodology page

Final prospectuses containing each signal, by sector. A count means the topic is disclosed, not that it is material
SignalBiotech and pharma (25)Medical device and diagnostics (11)Healthcare services (2)
Clinical evidence
Phase 125 / 250 / 110 / 2
Phase 225 / 251 / 110 / 2
Phase 325 / 251 / 110 / 2
Pivotal study18 / 254 / 110 / 2
Topline data24 / 251 / 110 / 2
Clinical hold25 / 254 / 110 / 2
Clinical validation13 / 256 / 110 / 2
Regulatory pathway
IND25 / 251 / 110 / 2
NDA or BLA25 / 251 / 110 / 2
Expedited designation24 / 250 / 110 / 2
510(k)3 / 2510 / 110 / 2
PMA or De Novo4 / 2511 / 110 / 2
Breakthrough Device0 / 254 / 110 / 2
CLIA or LDT0 / 252 / 110 / 2
CE mark or EU MDR/IVDR3 / 259 / 110 / 2
Quality and manufacturing
cGMP25 / 2511 / 110 / 2
Contract manufacturer25 / 259 / 110 / 2
QSR, QMSR or ISO 134852 / 2511 / 110 / 2
Form 483 or warning letter24 / 2511 / 110 / 2
Recall24 / 2511 / 111 / 2
Commercial operations
Reimbursement25 / 2511 / 112 / 2
CPT or HCPCS coding2 / 257 / 111 / 2
Medicare or Medicaid24 / 2511 / 112 / 2
Payer contracts24 / 2511 / 112 / 2
Value-based care0 / 254 / 111 / 2
Sales force24 / 2511 / 111 / 2
Healthcare compliance
HIPAA24 / 2511 / 112 / 2
Anti-Kickback Statute22 / 2511 / 112 / 2
Stark Law0 / 253 / 112 / 2
Corporate practice of medicine1 / 253 / 111 / 2
Certificate of need0 / 250 / 111 / 2
Financial disclosure
Auditor going-concern paragraph9 / 254 / 110 / 2
Material weakness identified8 / 253 / 111 / 2
Emerging growth company25 / 259 / 112 / 2
Cash runway statement21 / 253 / 110 / 2
Dual-class or controlled company4 / 255 / 111 / 2

03 / all issuers

The full cohort, with sources

Every row links to the final prospectus on SEC.gov. Profiles are one-line editor summaries of each prospectus overview, not quotations. Days to price run from the first draft or public registration submission shown on EDGAR

38 issuers shown

PricedIssuerSectorProfileDays to priceS-1/ASource
CapsoVision, IncLSH-2025Q3-78325 · CIK 1378325 Medical device and diagnostics Commercial-stage capsule endoscopy imaging with AI-assisted reading 146 3 424B4 ↗
CARLSMED, INC.LSH-2025Q3-94546 · CIK 1794546 Medical device and diagnostics Commercial-stage personalized spine surgery implants and planning software 91 1 424B4 ↗
SHOULDER INNOVATIONS, INC.LSH-2025Q3-99350 · CIK 1699350 Medical device and diagnostics Commercial-stage shoulder replacement systems 106 3 424B4 ↗
Heartflow, Inc.LSH-2025Q3-64521 · CIK 1464521 Medical device and diagnostics Commercial-stage AI software for non-invasive coronary artery disease diagnosis from CT scans 183 2 424B4 ↗
Curanex Pharmaceuticals IncLSH-2025Q3-25942 · CIK 2025942 Biotech and pharma Development-stage botanical drugs for inflammatory diseases 432 6 424B4 ↗
Picard Medical, Inc.LSH-2025Q3-30617 · CIK 2030617 Medical device and diagnostics Total artificial heart systems through its SynCardia subsidiary 375 7 424B4 ↗
LB PHARMACEUTICALS INCLSH-2025Q3-91082 · CIK 1691082 Biotech and pharma Clinical-stage therapies for schizophrenia and other neuropsychiatric diseases 480 1 424B4 ↗
BillionToOne, Inc.LSH-2025Q4-70849 · CIK 2070849 Medical device and diagnostics Molecular diagnostics lab tests in prenatal and oncology testing 139 1 424B4 ↗
Evommune, Inc.LSH-2025Q4-44725 · CIK 2044725 Biotech and pharma Clinical-stage therapies for chronic inflammatory diseases 176 1 424B4 ↗
Park Dental Partners, Inc.LSH-2025Q4-69604 · CIK 2069604 Healthcare services Dental support organization providing business services to affiliated practices 196 2 424B4 ↗
Lumexa Imaging Holdings, Inc.LSH-2025Q4-71288 · CIK 2071288 Healthcare services Outpatient diagnostic imaging centers 183 1 424B4 ↗
Medline Inc.LSH-2025Q4-46386 · CIK 2046386 Medical device and diagnostics Medical-surgical products and supply chain services at scale 364 2 424B4 ↗
Aktis Oncology, Inc.LSH-2026Q1-35832 · CIK 2035832 Biotech and pharma Clinical-stage targeted radiopharmaceuticals for oncology 455 2 424B4 ↗
Polaryx Therapeutics, Inc.LSH-2026Q1-75320 · CIK 2075320 Biotech and pharma Clinical-stage therapies for rare pediatric lysosomal storage disorders Direct listing 181 2 424B4 ↗
Veradermics, IncLSH-2026Q1-27635 · CIK 1827635 Biotech and pharma Late clinical-stage therapeutics for aesthetic and dermatological conditions 100 1 424B4 ↗
Eikon Therapeutics, Inc.LSH-2026Q1-61123 · CIK 1861123 Biotech and pharma Late-stage clinical biopharmaceutical pipeline across several indications 272 1 424B4 ↗
SpyGlass Pharma, Inc.LSH-2026Q1-78922 · CIK 1778922 Biotech and pharma Late-stage sustained-release drug delivery for chronic eye conditions 133 1 424B4 ↗
Generate Biomedicines, Inc.LSH-2026Q1-00782 · CIK 2100782 Biotech and pharma Clinical-stage generative-AI protein design and drug development 66 2 424B4 ↗
MiniMed Group, Inc.LSH-2026Q1-62583 · CIK 2062583 Medical device and diagnostics Scaled diabetes management devices, a carve-out from a larger device company 280 3 424B4 ↗
Alamar Biosciences, Inc.LSH-2026Q2-04204 · CIK 2104204 Medical device and diagnostics Commercial-stage proteomics instruments and assays 98 2 424B4 ↗
Kailera Therapeutics, Inc.LSH-2026Q2-96997 · CIK 2096997 Biotech and pharma Clinical-stage obesity therapeutics pipeline 119 1 424B4 ↗
Lakewood-Amedex Biotherapeutics Inc.LSH-2026Q2-79272 · CIK 2079272 Biotech and pharma Antimicrobial therapies for resistant pathogens Direct listing 266 5 424B4 ↗
Avalyn Pharma Inc.LSH-2026Q2-40171 · CIK 1540171 Biotech and pharma Clinical-stage inhaled therapies for rare respiratory diseases 83 2 424B4 ↗
Hemab Therapeutics Holdings, Inc.LSH-2026Q2-14044 · CIK 2114044 Biotech and pharma Clinical-stage therapies for blood coagulation disorders 63 3 424B4 ↗
Seaport Therapeutics, Inc.LSH-2026Q2-42347 · CIK 2042347 Biotech and pharma Clinical-stage medicines for depression, anxiety and neuropsychiatric disorders 161 1 424B4 ↗
Mobia Medical, Inc.LSH-2026Q2-89993 · CIK 1489993 Medical device and diagnostics Commercial-stage device for stroke motor recovery 107 2 424B4 ↗
Odyssey Therapeutics, Inc.LSH-2026Q2-82782 · CIK 1882782 Biotech and pharma Clinical-stage therapies for autoimmune and inflammatory diseases 578 1 424B4 ↗
Conexeu Sciences Inc.LSH-2026Q2-66836 · CIK 2066836 Medical device and diagnostics Collagen-based regenerative tissue products Direct listing 164 6 424B4 ↗
Parabilis Medicines, Inc.LSH-2026Q2-57677 · CIK 1657677 Biotech and pharma Clinical-stage medicines against historically undruggable protein targets 69 3 424B4 ↗
Kardigan, Inc.LSH-2026Q2-23613 · CIK 2123613 Biotech and pharma Clinical-stage precision therapeutics for cardiovascular disease 84 1 424B4 ↗
Scribe Therapeutics, Inc.LSH-2026Q3-53921 · CIK 1853921 Biotech and pharma Clinical-stage in vivo CRISPR genome-editing therapies 199 2 424B4 ↗
Apnimed, Inc.LSH-2026Q3-45648 · CIK 1745648 Biotech and pharma Late-stage oral therapies for obstructive sleep apnea and related breathing disorders 760 1 424B4 ↗
Attovia Therapeutics, Inc.LSH-2026Q3-58707 · CIK 2058707 Biotech and pharma Clinical-stage biotherapeutics for immune-mediated diseases 229 2 424B4 ↗
Braveheart Bio, Inc.LSH-2026Q3-31524 · CIK 2131524 Biotech and pharma Clinical-stage therapies for hypertrophic cardiomyopathy 99 1 424B4 ↗
BlossomHill Therapeutics, Inc.LSH-2026Q3-39970 · CIK 1839970 Biotech and pharma Clinical-stage small-molecule cancer therapeutics 105 1 424B4 ↗
Latigo Biotherapeutics, Inc.LSH-2026Q3-56611 · CIK 2056611 Biotech and pharma Clinical-stage non-opioid pain medicines 133 2 424B4 ↗
Vogenx, Inc.LSH-2026Q3-03784 · CIK 1903784 Biotech and pharma Clinical-stage therapies for metabolic disorders, including post-bariatric hypoglycemia 173 2 424B4 ↗
Electra Therapeutics, Inc.LSH-2026Q3-88082 · CIK 2088082 Biotech and pharma Late clinical-stage precision medicines for immune-mediated diseases and cancer 84 1 424B4 ↗

Download the complete source ledger, one row per SEC filing with its accession number and original link, as CSV or JSON (version 1.0.0)